Table 5

Mean HER2/CEN-17 ratio and signal numbers for all specimens.

Mean

N

Std. Deviation


HER2/CEN-17 ratio

HER2 CISH

1.64

352

1.21

HER2 FISH

1.78a

358

1.90

PathVysion

1.77b

361

1.83

HER2 signals

HER2 CISH

74.44

352

65.65

HER2 FISH

75.58c

358

92.92

PathVysion

71.76d

361

76.88

CEN-17 signals

HER2 CISH

43.89

352

11.98

HER2 FISH

41.20e

358

13.09

PathVysion

41.01f

361

21.88


Signal copy numbers were normalized to 20 nuclei

a) Significant different from CISH ratio in a two tailed, paired t-test (N = 348, P < 0.001)

b) Significant different from CISH ratio in a two tailed, paired t-test (N = 350, P = 0.001)

c) Not significant different from CISH HER2 signals in a two tailed, paired t-test (N = 348, P = 0.245)

d) Not significant different from CISH HER2 signals in a two-tailed, paired t-test (N = 350, P = 0.284)

e) Significant different from CISH CEN-17 signals in a two tailed, paired t-test (N = 348, P < 0.001)

f) Significant different from CISH CEN-17 signals in a two-tailed, paired t-test (N = 350, P < 0.003)

Mollerup et al. BMC Clinical Pathology 2012 12:3   doi:10.1186/1472-6890-12-3

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