Table 4

Cytokine production in response to stimulation in FM patients compared to healthy controls
Cytokine PHA
Controls Patients Cmean/ Pmean P-value
N Mean SD Min. Max. Med. N Mean SD Min. Max. Med.
MCP-1 90 3497 4384 69 >OOR 1823 109 1968 1993 86 >OOR 1310 1.8 0.003
IL-5 32 47.7 150.1 <OOR 853 14.1 48 7 17 <OOR 89 1.5 7 0.136
IL-6 91 2799 4182 1.2 15592 273 110 276 437 3.1 2255 108 10.2 <.001
IL-8 89 17456 24246 161 >OOR 4933 110 5751 6123 135 37981 3144 3 <.001
IL-10 65 80 94 <OOR 352 38 103 12 15 <OOR 84 6.8 6.5 <.001
IFNγ 70 1516 2425 <OOR 16902 670 101 569 1920 <OOR 15318 124 2.7 0.007
MIP-1α 91 1084 1773 1.9 9159 240 110 204 272 5.7 1598 109 5.3 <.001
MIP-1β 83 4413 5228 122 >OOR 2282 109 2900 2417 395 >OOR 2259 1.5 0.016
Cytokine PMA/Ionomycin
Controls Patients Cmean/ Pmean P- value
N Mean SD Min. Max. Med. N Mean SD Min. Max. Med.
MCP-1 91 1224 1126 150 8295 874 108 436 421 <OOR 2363 292 2.8 <.001
IL-5 87 63.8 63.9 <OOR 374.5 42.5 98 36 54 <OOR 441 17 1.8 0.002
IL-6 91 532 474 26 2108 350 108 242 301 <OOR 1509 109 2.2 <.001
IL-8 90 17607 10103 5724 >OOR 13677 109 8756 6416 215 >OOR 7503 2 <.001
IL-10 87 63 60 <OOR 254 40 90 27 37 <OOR 230 11 2.4 <.001
IFNγ 91 36726 55772 205 339591 16130 103 14584 23047 <OOR 144516 5636 2.5 0.001
MIP-1α 90 1246 1051 105 >OOR 987 109 308 294 <OOR 1551 191 4 <.001
MIP-1β 80 6389 4915 254 >OOR 5177 106 3086 4040 9.5 >OOR 1517 2.1 <.001

Concentrations of cytokines in pg/ml are shown.

N, number of subjects whose cytokine values were within the detection ranges.

OOR, out of range.

Behm et al.

Behm et al. BMC Clinical Pathology 2012 12:25   doi:10.1186/1472-6890-12-25

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