Table 1

Patient clinicopathological characteristics and their correlation with MMP-2, MMP-8, and MMP-9 immunoreactivity in colorectal cancer patients assessed with chi-square test
MMP-2 MMP-8 MMP-9
Clinicopathological Patients positive p-value Patients positive p-value Patients positive p-value
variable (n=) (n) % (n=) (n) % (n=) (n) %
Gender 0.887 0.496 0.574
Female 272 153 56.3 257 194 75.5 257 158 61.5
Male 309 172 55.7 301 235 78.1 301 192 63.8
Age 0.107 0.343 0.197
< 65 years 244 146 59.8 228 183 80.3 238 142 59.7
≥ 65 years 337 179 53.1 320 246 76.9 320 208 65.0
Dukes’ stage 0.317 0.148 0.100
A 87 44 50.6 82 63 76.8 83 57 68.7
B 208 110 52.9 197 163 82.7 206 138 67.0
C 155 93 60.0 137 99 72.3 138 77 55.8
D 131 78 59.5 132 104 78.8 131 78 59.5
Dukes’ stage 0.066 0.116 0.016*
A and B 295 154 52.2 279 226 81.0 289 195 67.5
C and D 286 171 59.8 269 203 75.5 269 155 57.6
Differentiation (WHO grade) 0.116 0.326 <0.001*
1 19 9 47.4 19 14 73.7 18 12 66.7
2 382 211 55.2 368 290 78.8 374 254 67.9
3 155 86 55.5 138 111 80.4 142 77 54.2
4 24 19 79.2 22 14 63.6 23 7 30.4
missing 1 1 1
Histologic type 0.680 0.085 0.053
Adenocarcinoma 512 288 56.3 481 382 79.4 489 314 64.2
Mucinous carcinoma 69 37 53.6 67 47 70.1 69 36 52.2
Tumour location 0.202 0.073 0.419
Colon 315 169 53.7 305 247 81.0 311 191 61.4
Rectum 263 155 58.9 240 179 74.6 244 158 64.8
missing 3 3 3

* = p-value significant.

Koskensalo et al.

Koskensalo et al. BMC Clinical Pathology 2012 12:24   doi:10.1186/1472-6890-12-24

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