Immunohistochemical expression of LSD1 in pre-invasive and invasive ductal breast carcinoma. (A, B) Low grade DCIS shows weak nuclear LSD1 expression (IRS = 4). (C, D) In intermediate grade ductal carcinoma in situ LSD1 expression is more intense (IRS = 8) than in low grade ductal breast cancer. (E, F) In high grade ductal carcinoma in situ LSD1 expression is more abundant (IRS = 12) compared with low grade and intermediate grade ductal carcinoma in situ. (G, H) In invasive ductal breast carcinoma LSD1 expression is as strong as in high grade ductal carcinoma (IRS = 12). Magnification A-H: 100x.
Serce et al. BMC Clinical Pathology 2012 12:13 doi:10.1186/1472-6890-12-13