Table 2

Association of automated assessment of Ki-67 extent of staining with clinicopathological characteristics

Characteristic

    Automated assessment of Ki-67 extent of staining

P

Low N (%)

Moderate N (%)

High N (%)


All tissue samples (N = 1334) *

406 (30)

446 (33)

482 (36)

Ki-67 expression (visual)

High

13 (3)

102 (22)

359 (76)

< 0.0001

Moderate

293 (41)

314 (44)

112 (16)

Negative

82 (83)

15 (15)

2 (2)

Not available

18 (43)

15 (36)

9 (21)

Age at diagnosis (y)

< 35

2 (6)

13 (36)

21 (58)

0.0008

35-50

101 (28)

120 (33)

141 (39)

50-65

160 (36)

133 (30)

149 (34)

>65

143 (29)

180 (36)

171 (35)

Method of detection

Mammography screening

102 (41)

81 (33)

66 (27)

0.0001

Other

298 (28)

355 (34)

403 (38)

Not available

6 (21)

10 (34)

13 (45)

Primary tumour diameter (cm)

< 0.5

8 (44)

8 (44)

2 (11)

< 0.0001

0.5-1

82 (42)

66 (34)

49 (25)

1-2

182 (34)

180 (34)

172 (32)

2-5

104 (22)

156 (33)

212 (45)

> 5

13 (24)

14 (25)

28 (51)

Not available

17 (29)

22 (38)

19 (33)

No. of positive axillary nodes

0

276 (35)

253 (32)

264 (33)

0.0142

1-3

80 (27)

98 (33)

119 (40)

4-9

26 (23)

45 (40)

41 (37)

≥ 10

5 (16)

11 (35)

15 (48)

Not available

19 (19)

39 (39)

43 (43

Histological grade

1

118 (52)

73 (32)

37 (16)

< 0.0001

2

122 (26)

184 (39)

171 (36)

3

34 (12)

67 (23)

188 (65)

Not available

132 (39)

122 (36)

86 (25)

Histological type

Ductal

275 (27)

342 (34)

402 (40)

< 0.0001

Lobular

87 (46)

67 (35)

36 (19)

Special

44 (35)

37 (30)

44 (35)

ER expression

Positive

301 (35)

324 (38)

234 (27)

< 0.0001

Negative

69 (17)

102 (26)

228 (57)

Not available

36 (47)

20 (26)

20 (26)

PR expression

Positive

254 (37)

270 (39)

171 (25)

< 0.0001

Negative

122 (21)

151 (27)

295 (52)

Not available

30 (42)

25 (35)

16 (23)

HER2 amplification

Positive

34 (14)

75 (31)

134 (55)

< 0.0001

Negative

331 (33)

333 (34)

327 (33)

Not available

41 (41)

38 (38)

21 (21)

HER2 expression

Positive

26 (13)

60 (29)

121 (58)

< 0.0001

Negative

333 (33)

340 (34)

324 (33)

Not available

47 (36)

46 (35)

37 (28)

p53 expression

High

16 (7)

50 (22)

158 (71)

< 0.0001

Moderate

98 (27)

135 (37)

129 (36)

Low

222 (39)

196 (34)

155 (27)

Not available

70 (40)

65 (37)

40 (23)

Molecular subtype

Basal

11 (12)

15 (16)

69 (73)

< 0.0001

HER2+/HR-

14 (12)

33 (28)

70 (60)

Luminal A

291 (38)

288 (37)

191 (25)

Luminal B

19 (16)

37 (32)

60 (52)

Five-marker negative

8 (19)

6 (14)

28 (67)

Unclassified

9 (16)

18 (32)

29 (52)

Not available

54 (39)

49 (36)

35 (25)


* due to ties the number of samples in each tertile is not equal

Konsti et al. BMC Clinical Pathology 2011 11:3   doi:10.1186/1472-6890-11-3

Open Data