Immunohistochemical profile of OSCC with sarcomatoid component, Case 1. A, SNAI1; B, E-cadherin; C, FAK and D, p63 are differentially expressed in sarcomatoid (A+C) and squamous (B+D) component. Magnified inserts correspond to framed areas in the section overview. An asterisk in insert C indicates strands of squamous cell carcinoma intermingled with the sarcomatoid component. Dual staining of SNAI1 (nuclear, brown) and E, HMWK or F, Vimentin (red) illustrates the mesenchymal character of the sarcomatoid tumor component. G, Lymph node metastasis with focal E-cadherin loss (arrow).
Schwock et al. BMC Clinical Pathology 2010 10:1 doi:10.1186/1472-6890-10-1