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Effect of naloxone on the anticonvulsant activity of Pasipay in PTZ-induced convulsion in mice |
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| Treatment (dose) |
Onset (sec) |
Duration (sec) |
Mortality protection (%) |
|
|
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| Normal saline (10 ml/kg) |
51.83 ± 64 |
12 ± 1.80 |
0 |
| Naloxone (5 mg/kg) |
10.66 ± 0.66 |
49.6 ± 4.34 |
0 |
| Pasipay (0.4 mg/kg) |
600 ± 0*** |
0 ± 0*** |
100 |
| Pasipay+ Naloxone |
125.4 ± 2.87*** |
8.81 ± 2.64 |
40 |
|
Normal saline and Pasipay were administered (i.p.) 30 min before the injection of PTZ (90 mg/kg, i.p.); Naloxone was administered 35 min before the injection of PTZ (90 mg/kg, i.p.); Values are the mean ± S.E.M. for 10 mice; *** p < 0.001, compared to saline group, Tukey-Kramer test. | |||
Nassiri-Asl et al. BMC Complementary and Alternative Medicine 2007 7:26 doi:10.1186/1472-6882-7-26 |
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