Table 6

Experiment B: Carageenan edema and oral administration

Drug

Paw volume increase over time (ml ± SD) and effect (% of negative control)


1 hr

3 hr

5 hr

7 hr


Saline

0.39 ± 0.17

0.77 ± 0.16

0.63 ± 0.18

0.54 ± 0.16

Apis D4

0.37 ± 0.11

-7

0.81 ± 0.11

+6

0.70 ± 0.20

+12

0.60 ± 0.15

+11

Apis D30

0.43 ± 0.11

+8

0.82 ± 0.11

+7

0.73 ± 0.17

+16

0.59 ± 0.13

+10

Lachesis D6

0.40 ± 0.12

+1

0.79 ± 0.19

+3

0.71 ± 0.18

+14

0.58 ± 0.17

+7

Lachesis D30

0.40 ± 0.17

+2

0.79 ± 0.19

+3

0.75 ± 0.19

+19

0.59 ± 0.21

+10

Phosphorus D6

0.40 ± 0.15

+1

0.80 ± 0.18

+4

0.70 ± 0.16

+11

0.59 ± 0.20

+10

Phosphorus D30

0.41 ± 0.16

+3

0.85 ± 0.23

+11

0.72 ± 0.21

+14

0.59 ± 0.18

+10

Indomethacin i.m.

0.30 ± 0.14

-24

0.48 ± 0.15

-38

0.52 ± 0.10

-18

0.43 ± 0.10

-20


ANOVA results for measurements from 1 to 7 hrs since edema induction. Treatment: F(7,14) = 4.23, p = 0.0105; Time: (F(3,6) = 26.91, p = 0.0007; Treatment × time (different profiles over time between treatments): F(21,42) = 2.07, p = 0.1010; Replication × time (different profiles over time between replications): F(6,45) = 8.61, p < 0.0001; Replication × treatment × time (different profiles over time between replications and treatments): F(42,315) = 1.65, p = 0.0110.

Bold characters denote significant comparisons (by Student t test) vs. Saline group corresponding for time since edema induction.

Conforti et al. BMC Complementary and Alternative Medicine 2007 7:1   doi:10.1186/1472-6882-7-1

Open Data