Table 1

General scheme of the study



Phase A
 Phase B
Randomisation




     by cages



     within cages by treatments

-
Blinding




     Treatment administration

-
     Edema measurement



Inflammation model

CA
 BL
 CA
Homeopathic remedies





dilution
 n. of animals studied






     Arnica
 D4
 71
 O/I
 O/I
 -
     Apis
 D4
 90
 O/I
 O/I
 O
     Apis
 D30
 18
 -
 -
 O
     Atropa
 D4
 72
 O/I
 O/I
 -
     Hamamelis
 D4
 72
 O/I
 O/I
 -
     Lachesis
 D6
 86
 O/I
 O/I
 O
     Lachesis
 D30
 18
 -
 -
 O
     Phosphorus
 D6
 90
 O/I
 O/I
 O
     Phosphorus
 D30
 18
 -
 -
 O






Reference treatments




     Placebo:




          Physiological solution
86
 O/I
 O/I
 O
     Active comparator:




          Indomethacin
88
 I/I
 I/I
 I

O = oral administration

I = administration through injection

CA = carrageenan induced edema

BL = autologous blood induced edema

Each treatment group has been tested through 3 replications. In each replication 6 rats were studied. In experiment A 11 rats were excluded from the analyses because of problems with edema induction.

Conforti et al. BMC Complementary and Alternative Medicine 2007 7:1   doi:10.1186/1472-6882-7-1