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Open Access Research article

Aqueous extract of dioscorea opposita thunb. normalizes the hypertension in 2K1C hypertensive rats

Nurmuhammat Amat1*, Raziya Amat1, Sajida Abdureyim2, Parida Hoxur3, Zulpiya Osman1, Dolkun Mamut4* and Anake Kijjoa5

Author Affiliations

1 Traditional Uighur Medicine Institute, Xinjiang Medical University, 830011 Urumqi, Xinjiang, PR China

2 First Affiliated Hospital, Xinjiang Medical University, 830011 Urumqi, Xinjiang, PR China

3 Traditional Chinese Medicine Hospital, Xinjiang Medical University, 830011 Urumqi, Xinjiang, PR China

4 Salamat Biotechnology Co., Ltd, Urumqi, Xinjiang 830011 PR China

5 ICBAS-Instituto de Ciências Biomédicas de Abel Salazar and CIIMAR, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal

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BMC Complementary and Alternative Medicine 2014, 14:36  doi:10.1186/1472-6882-14-36

Published: 21 January 2014

Abstract

Background

Dioscorea opposita Thunb. (Huai Shan Yao, DOT), a common staple food in China, has been used for more than 2000 years in traditional Chinese medicine (TCM) to treat different systemic diseases including hypertension. The objective of this study was to investigate the possible antihypertensive effects of the aqueous extract of (DOT) in renovascular hypertensive rats as well as the mechanism in reducing blood pressure.

Methods

The two-kidney one-clip (2K1C) Goldblatt model of renovascular hypertension was used in Wistar rats. Rats with captopril, low-dose DOT and high-dose DOT treated 2K1C groups for 6 weeks. The blood pressure, cardiac mass index (heart weight/body weight), plasma level of angiotensin-II (Ang-II), endothelin-1(ET-1), superoxide dismutase (SOD) and malondialdehyde (MDA) were evaluated.

Results

DOT significantly reduced mean systolic and diastolic blood pressure after treatment. DOT also significantly increased plasma SOD activity but decreased plasma MDA concentration. Renal function was improved with captopril and DOT. DOT reduced plasma Ang-II activity and plasma ET concentration. They couldalso significantly reduce the left ventricular hypertrophy and cardiac mass index.

Conclusions

Our results suggest that DOT may have an antihypertensive effect on hypertension by inhibit ET-converting enzyme and antioxidant activity, which warrant further exploration.

Keywords:
Antihypertensive; Dioscorea opposite Thunb; 2K1C experimental hypertension; Angiotensin-II; Endothelin-1; Hypertrophy