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Open Access Research article

Anti-hyperglycemic effects of three medicinal plants in diabetic pregnancy: modulation of T cell proliferation

Akadiri Yessoufou1*, Joachim Gbenou2, Oussama Grissa3, Aziz Hichami4, Anne-Marie Simonin5, Zouhair Tabka3, Mansourou Moudachirou2, Kabirou Moutairou1 and Naim A Khan5

Author Affiliations

1 Laboratory of Cell Biology and Physiology, Department of Biochemistry and Cellular Biology, Faculty of Sciences and Techniques (FAST) and Institute of Applied Biomedical Sciences (ISBA), University of Abomey-Calavi, Cotonou, 01 BP 918, Benin

2 Laboratory of Pharmacognosy and Essential Oils (ISBA/FAST), University of Abomey-Calavi, Cotonou, 01 BP 918, Benin

3 Department of Physiology and Functional Exploration, University Hospital Farhat Hached, Sousse, 4000, Tunisia

4 INSERM U866, University of Bourgogne, 6 BD Gabriel, Dijon, 21000, France

5 University of Bourgogne, Physiology of Nutrition and Toxicology, INSERM UMR866, AgroSup/UB, Faculty of Life Sciences, 6 Boulevard Gabriel, Dijon, 21000, France

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BMC Complementary and Alternative Medicine 2013, 13:77  doi:10.1186/1472-6882-13-77

Published: 8 April 2013

Abstract

Background

Populations in Africa mostly rely on herbal concoctions for their primarily health care, but so far scientific studies supporting the use of plants in traditional medicine remain poor. The present study was undertaken to evaluate the anti-hyperglycemic effects of Picralima nitida (seeds), Nauclea latifolia (root and stem) and Oxytenanthera abyssinica (leaves) commonly used, in diabetic pregnancy.

Methods

Pregnant wistar rats, rendered diabetic by multiple low injections of streptozotocin, were treated with selected plant extracts based on their antioxidant activities. Vitamin C concentrations, fatty acid compositions and phytochemical analysis of plants extracts were determined. Effect of selected plant extracts on human T cell proliferation was also analysed.

Results

All analysed plant extracts exhibited substantial antioxidant activities probably related to their content in polyphenols. Picralima nitida exhibited the highest antioxidant capacity. Ethanolic and butanolic extracts of Picralima nitida, butanolic extract of Nauclea latifolia and ethanolic extract of Oxytenanthera abyssinica significantly decreased hyperglycemia in the diabetic pregnant rats. Butanolic extract of Picralima, also appeared to be the most potent immunosuppressor although all of the analysed extracts exerted an immunosuppressive effect on T cell proliferation probably due to their linolenic acid (C18:3n-3) and/or alkaloids content. Nevertheless, all analysed plants seemed to be good source of saturated and monounsaturated fatty acids.

Conclusion

By having antioxidant, anti-hyperglycemic and immunosuppressive activities, these plants could be good candidates in the treatment of diabetes and diabetic pregnancy.

Keywords:
Medicinal plants; Diabetic pregnancy; Antioxidants; T-cell proliferation; Fatty acids