Open Access Research article

Dietary grape polyphenol resveratrol increases mammary tumor growth and metastasis in immunocompromised mice

Linette Castillo-Pichardo12, Luis A Cubano3 and Suranganie Dharmawardhane1*

  • * Corresponding author: Suranganie Dharmawardhane su.d@upr.edu

Author Affiliations

1 Department of Biochemistry, School of Medicine, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, Puerto Rico

2 Department of Pathology and Laboratory Medicine, Universidad Central del Caribe School of Medicine, Bayamon, Puerto Rico

3 Department of Anatomy and Cell Biology, Universidad Central del Caribe School of Medicine, Bayamon, Puerto Rico

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BMC Complementary and Alternative Medicine 2013, 13:6  doi:10.1186/1472-6882-13-6

Published: 8 January 2013

Additional files

Additional file 1:

Figure S1. Effect of resveratrol on mice weight. GFP-tagged MDA-MB-231 or MDA-MB-435 cells (1 × 106) in Matrigel:DMEM (1:1) were inoculated at the mammary fat pad of female SCID (MDA-MB-231) or athymic nude mice (MDA-MB-435). One week following injection, mice were fed vehicle (Veh) or 0.5, 5, or 50 mg/kg BW resveratrol (Res) 5 times a week by oral gavage. Mice weights were recorded every two weeks to monitor toxicity and are presented for (A) the MDA-MB-231 study and (B) the MDA-MB-435 study, as a function of days. Differences between means were determined using Student’s t-Test.

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