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This article is part of the supplement: Scientific Abstracts Presented at the International Research Congress on Integrative Medicine and Health 2012

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OA02.03. Nutrient biomarker patterns and rates of cognitive decline in dementia-free elders

G Bowman*, J Quinn, J Kaye and J Shannon

  • * Corresponding author: G Bowman

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Oregon Health & Science University, Portland, USA

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Citation and License

BMC Complementary and Alternative Medicine 2012, 12(Suppl 1):O7  doi:10.1186/1472-6882-12-S1-O7

The electronic version of this article is the complete one and can be found online at:

Published:12 June 2012

© 2012 Bowman et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We previously identified three distinct nutrient biomarker patterns associated with both psychometric and neuroimaging indices of brain health in a cross-sectional analysis. The objective of this study was to examine the relationship between the nutrient biomarker patterns and cognitive decline over 2 years.


Thirty biological markers of diet were assayed in plasma from 104 dementia-free elders in the Oregon Brain Aging Study. Principal component analysis constructed distinct nutrient biomarker patterns. A linear regression model was used to assess the association between NBPs and rate of change in Clinical Dementia Rating - sum of box score over two years.


Mean age was 87±10, 62% were female, and 10% were carrying the ApoEe4 allele. Two distinct nutrient biomarker patterns were associated with rates of cognitive decline: a vitamin pattern high in B, C, E and D (p=0.001) and a high trans fat pattern (p<0.001) associated with less and more decline over two years, respectively. These findings were independent of age, gender, education years, ApoEe4 carrier status and vascular risk factors.


A plasma nutrient profile high in certain vitamins and low in trans-fat may be prudent for maintaining cognitive function in older populations.