Table 1

Effect of auraptene and lacinartin on the activity of MMP-9 and P. gingivalis collagenase
Compound MMP-9 (% activity) Collagenase (% activity)
None 100 ± 1 100 ± 3
Commercial inhibitor1 56 ± 1 6 ± 5
Auraptene 100 μg/ml 27 ± 1 110 ± 4
50 27 ± 1 113 ± 5
25 27 ± 3 113 ± 1
12.5 26 ± 1 107 ± 10
Lacinartin 100 μg/ml 19 ± 6 36 ± 3
50 25 ± 1 49 ± 1
25 31 ± 2 69 ± 1
12.5 26 ± 3 80 ±1

1Inhibitor of MMP-9: GM6001 (0.025 μM); inhibitor of P. gingivalis collagenase: leupeptin (1 μM).

Marquis et al.

Marquis et al. BMC Complementary and Alternative Medicine 2012 12:80   doi:10.1186/1472-6882-12-80

Open Data