Open Access Research article

The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats

Hui Chen12, Jun Yin2, Yanpin Deng1, Min Yang1, Lingling Xu1, Fukang Teng12, Defang Li1, Yufan Cheng3, Sha Liu4, Dong Wang2, Tingting Zhang12, Wanying Wu1, Xuan Liu1, Shuhong Guan1, Baohong Jiang1* and Dean Guo1*

Author Affiliations

1 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Haike Road #501, Shanghai, 201203, China

2 Shenyang Pharmaceutical University, Wenhua Road #103, Shenyang, 110016, China

3 Fudan University Shanghai Cancer Center, Dongan Road #270, Shanghai, 200023, China

4 School of Medicine, Shanghai Jiaotong University, Dongfang Road #1630, Shanghai, 200127, China

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BMC Complementary and Alternative Medicine 2012, 12:53  doi:10.1186/1472-6882-12-53

Published: 25 April 2012

Additional files

Additional file 1:

Figure S1. The representative chromatogram of high-performance liquid chromatography for Rg1. Agilent 1100 HPLC system was used and the detection wavelength was set at 280 nm. The mobile phase consisted of (A) acetonitrile and (B) 0.05% aqueous trifluoroacetic acid (V/V), using a gradient elution of 2%-10% A at 0–7 min, 10%–30% A at 7–20 min, 23%–27% A at 20–35 min, and 27%–60% A at 35–50 min .

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Additional file 2:

Figure S2.13C NMR spectrum of Rg1 detected by Bruker AM-400 spectrometer.

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Additional file 3:

Figure S3. Structure elucidation of Rg1. (A) Chemical structure of Rg1. (B)13C NMR (100 MHz) spectral data for Rg1.

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Additional file 4:

Figure S4. Experimental protocol. Rg1 treatment was performed from week 9 to week 12.

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