Table 3

Hematological values of animals treated with SST for 4 weeks
Dose (mg/kg/day) 0 500 1000 2000
Male rat
WBC (103/μL) 11.05 ± 2.35a 12.76 ± 1.78 12.68 ± 3.36 9.14 ± 2.40
Reticulocyte (%) 2.7 ± 0.42 2.7 ± 0.20 3.0 ± 0.73 2.3 ± 0.23
Neutrophils (%) 9.18 ± 2.34 11.28 ± 3.40 10.32 ± 2.35 14.60 ± 2.78*
Lymphocytes (%) 86.5 ± 3.26 81.9 ± 3.25 84.6 ± 2.67 80.1 ± 3.62*
Eosinophils (%) 0.8 ± 0.40 0.6 ± 0.09 0.6 ± 0.22 0.5 ± 0.12
Monocytes (%) 2.0 ± 0.59 2.7 ± 0.66 2.6 ± 0.63 2.6 ± 0.56
Basophils (%) 0.8 ± 0.20 1.1 ± 0.22 1.0 ± 0.21 1.3 ± 0.35
Large unstained cells (%) 0.7 ± 0.24 2.4 ± 2.97 0.9 ± 0.16 1.0 ± 0.34
RBC (106/μL) 8.04 ± 0.16 8.33 ± 0.43 8.15 ± 0.38 8.22 ± 0.55
Hemoglobin (g/dl) 15.8 ± 0.51 16.2 ± 0.58 16.1 ± 0.52 15.8 ± 0.49
Hematocrit (%) 47.7 ± 2.12 48.3 ± 1.98 48.1 ± 1.75 48.0 ± 1.76
MCV (fL) 59.2 ± 1.64 58.1 ± 1.68 59.0 ± 1.34 58.5 ± 1.79
MCH (pg) 19.6 ± 0.32 19.4 ± 0.61 19.8 ± 0.38 19.3 ± 0.75
MCHC (g/dl) 33.1 ± 0.37 33.5 ± 0.73 33.5 ± 0.44 32.9 ± 0.31
Platelet (103/μL) 1305 ± 225 1164 ± 40 1198 ± 67 1178 ± 66
PT (sec) 17.5 ± 0.86 17.2 ± 0.45 16.5 ± 0.87 16.7 ± 0.62
APTT (sec) 16.3 ± 0.80 16.7 ± 0.80 15.4 ± 1.11 16.3 ± 0.49
Female rat
WBC (103/μL) 8.07 ± 1.25 8.17 ± 2.38 8.27 ± 1.09 6.75 ± 0.56
Reticulocyte (%) 2.2 ± 0.38 2.7 ± 0.39 2.4 ± 0.58 2.5 ± 0.55
Neutrophils (%) 13.12 ± 6.54 15.92 ± 7.16 15.58 ± 5.63 13.20 ± 3.05
Lymphocytes (%) 81.6 ± 6.97 78.6 ± 7.19 79.2 ± 5.09 82.7 ± 2.81
Eosinophils (%) 1.0 ± 0.15 1.3 ± 0.38 1.1 ± 0.15 0.8 ± 0.17
Monocytes (%) 2.2 ± 0.86 2.6 ± 0.40 2.4 ± 0.61 1.7 ± 0.35
Basophils (%) 0.9 ± 0.21 0.8 ± 0.25 0.7 ± 0.13 0.9 ± 0.13
Large unstained cells (%) 1.2 ± 0.42 0.9 ± 0.23 1.0 ± 0.08 0.8 ± 0.26
RBC (106/μL) 8.24 ± 0.33 8.28 ± 0.16 8.18 ± 0.20 8.14 ± 0.13
Hemoglobin (g/dl) 15.9 ± 0.55 15.7 ± 0.44 16.0 ± 0.13 15.7 ± 0.19
Hematocrit (%) 46.4 ± 1.62 46.4 ± 1.06 47.0 ± 0.43 46.2 ± 0.73
MCV (fL) 56.4 ± 0.88 56.0 ± 1.67 57.5 ± 1.25 56.8 ± 0.49
MCH (pg) 19.3 ± 0.43 19.0 ± 0.54 19.6 ± 0.50 19.4 ± 0.35
MCHC (g/dl) 34.3 ± 0.28 33.9 ± 0.38 34.1 ± 0.40 34.1 ± 0.49
Platelet (103/μL) 1242 ± 76 1595 ± 430 1161 ± 100 1132 ± 32
PT (sec) 17.6 ± 0.43 18.1 ± 0.26 17.6 ± 0.59 18.3 ± 0.73
APTT (sec) 13.9 ± 0.39 15.4 ± 0.86 14.3 ± 1.10 14.8 ± 0.75

APTT, activated partial thromboplastin time; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; PT, prothrombin time.

a Values are presented as mean ± SD.

* Indicate a significant difference at P < 0.05 level, when compared with the vehicle control group.

Shin et al.

Shin et al. BMC Complementary and Alternative Medicine 2012 12:266   doi:10.1186/1472-6882-12-266

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