Histopathological effects of ACA and CDDP treatment on HSC-4 human oral squamous carcinoma xenograft tumor biopsies against members of the NF-κB pathway and NF-κB regulated genes. IHC analysis indicates an increase in IκBα protein levels and a reduction in p65, phospho-IKKα/β, COX-2 and cyclin D1 protein levels on sections treated with standalone ACA and ACA in combination with CDDP. Blue color indicates nuclei stained with hematoxylin and brown color indicates specific DAB antibody staining. All images were shown as a representative of three independent replicates at 400X magnification.
In et al. BMC Complementary and Alternative Medicine 2012 12:179 doi:10.1186/1472-6882-12-179