Open Access Research article

Kalanchoe tubiflora extract inhibits cell proliferation by affecting the mitotic apparatus

Yi-Jen Hsieh15, Ming-Yeh Yang2, Yann-Lii Leu4, Chinpiao Chen5, Chin-Fung Wan67, Meng-Ya Chang38 and Chih-Jui Chang2*

Author Affiliations

1 Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Hualien, 97004, Taiwan

2 Department of Molecular Biology and Human Genetics, Tzu Chi University, No. 701, Zhongyang Rd., Sec. 3, Hualien, 97004, Taiwan

3 Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan

4 Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan

5 Department of Chemistry, National Dong-Hwa University, Hualien, Taiwan

6 School of Applied Chemistry, Chung Shan Medical University, No.110,Sec.1,Jianguo N.Road, Taichung City, 40201, Taiwan

7 Institute of NanoEngineering and MicroSystems, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan

8 Department of Medical Research, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan

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BMC Complementary and Alternative Medicine 2012, 12:149  doi:10.1186/1472-6882-12-149

Published: 10 September 2012

Additional files

Additional file 1:

Figure S1. The toxicity of KT-NB was less in normal cells. (A) Normal female embryonic lung cells (WI-38) and lung cancer cells (A549) were treated with different concentrations of KT-NB (1.35 μg/ml, 6.75 μg/ml, 13.5 μg/ml and 25 μg/ml). DMSO was used as a control. Cells were harvested for MTT assay at different time points. The absorbance of the control group was defined as 100%. Results were based on three independent experiments. (B) Cell morphology of WI-38 was unaffected after KT-NB treatment for 72 h.

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