GSPs inhibit SCC13 cell invasion by inhibiting activation of ERK1/2. (A) GSPs inhibit the activation of ERK1/2 in SCC13 cells dose-dependently. (B) Treatment of SCC13 cells with MEK inhibitor (UO126, 80 μM) inhibits the invasion of cells compared to non-MEK inhibitor-treated control cells. (C) The data on cell invasion capacity are summarized and expressed as the mean number of invasive cells ± SD/microscopic field, n = 3. Significant difference versus control *P < 0.001. (D) The treatment of cells with MEK inhibitor also inhibits the activation of ERK1/2 in cells as determined by western blot analysis. Representative blot is shown from three separate experiments.
Sun et al. BMC Complementary and Alternative Medicine 2011 11:134 doi:10.1186/1472-6882-11-134