Open Access Highly Accessed Research article

Characterization of Salvia Miltiorrhiza ethanol extract as an anti-osteoporotic agent

Yan Cui1, Bidur Bhandary1, Anu Marahatta1, Geum-Hwa Lee2, Bo Li1, Do-Sung Kim1, Soo-Wan Chae1, Hyung-Ryong Kim2* and Han-Jung Chae1*

Author Affiliations

1 Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk National University, Jeonju, Chonbuk, South Korea

2 Department of Dental Pharmacology and Wonkwang Dental Research Institute, School of Dentistry, Wonkwang University, Iksan, Chonbuk, South Korea

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BMC Complementary and Alternative Medicine 2011, 11:120  doi:10.1186/1472-6882-11-120

Published: 28 November 2011

Additional files

Additional file 1:

Chromatogram of constituents from SM extracts by HPLC analysis. The chromatogram shows peaks about Tanshinone IIA and cryptotanshinone. The retention time for cryptotanshinone and tanshinone IIA was 14.8 and 21.6 min. The content of tanshinone IIA and cryptotanshinone in Salvia Miltiorrhiza was 106.56 μg/10 mg (1.07%) and 109.655 μg/10 mg (1.10%).

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Additional file 2:

HPLC analysis methods for measurement of the standards of Tanshinone IIA and Cryptotanshinone. The Additional file shows HPLC analysis method for the standard chemicals "Tanshinone IIA and Cryptotanshinone".

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Additional file 3:

Changes in body weight growth in rats. The additional file shows the rat's body weights from the second week after OVX (including OVX and all drug administration groups).

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Additional file 4:

Coronal image of proximal-medial tibia taken ex vivo by μ-CT. The additional file shows conditions for μ-CT (references Set distal growth plate as reference level and 8 mm distal from distal growth plate as cortical area analysis cut level and the related transaxial image of tibial diaphysis).

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