Table 3

The association between estrogenic botanical supplement (EBS) use and total fatigue score

Association with continuous total fatigue score

Association with severe fatigue (≥ 4)


No.

Adjusted regression coefficient (standard error)

P value

No. with PFS < 4

No. with PFS ≥ 4

Adjusted OR (95% CI)


Ever used EBS after diagnosisa

No

464

280

184

1.00

Yes

303

0.13 (0.17)

0.44

179

124

1.06 (0.78-1.45)

By number of EBS useda

1

141

0.11 (0.21)

0.59

86

55

0.98 (0.66-1.46)

≥ 2

162

0.14 (0.21)

0.50

93

69

1.14 (0.78-1.69)

By type of EBS useda, b

Soy supplements

127

0.07 (0.23)

0.75

75

52

1.16 (0.74-1.80)

Ginseng

103

0.81 (0.26)

0.002

54

49

1.70 (1.04-2.76)

Flaxseed oil

100

-0.22 (0.26)

0.40

66

34

0.66 (0.39-1.12)

Black cohosh

68

-0.17 (0.32)

0.60

43

25

0.78 (0.41-1.46)

Yam

47

-0.003 (0.37)

0.99

30

17

0.94 (0.45-1.96)

Dong quai

39

-0.25 (0.40)

0.53

24

15

0.83 (0.38-1.81)

Red clover

38

-0.60 (0.42)

0.15

26

12

0.52 (0.22-1.21)

Licorice

37

0.07 (0.40)

0.85

21

16

1.41 (0.65-3.06)

Alfalfa

31

-0.39 (0.43)

0.36

21

10

0.72 (0.30-1.71)

Cat's claw

24

0.79 (0.49)

0.11

12

12

2.03 (0.76-5.42)

DHEA

24

0.27 (0.45)

0.55

11

13

1.96 (0.82-4.70)

Other EBS

34

-0.57 (0.41)

0.16

22

12

0.79 (0.35-1.77)


aAdjusted for education, age at diagnosis, medical comorbidity, activity level within the past year of 30-month interview, a combined variable for menopause and hormone therapy, isoflavones from soy-containing foods. bAdditionally, all types mutually adjusted.

Ma et al. BMC Complementary and Alternative Medicine 2011 11:109   doi:10.1186/1472-6882-11-109

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