Table 3

Effect of the methanolic extract of the fruits of Terminalia chebula, Terminalia belerica and Emblica officinalis on the activities of antioxidant enzymes and reduced glutathione content in liver of normal mice

Tested Parameters


Tested Samples

SOD (U/mg protein)

CAT (U/mg protein)

GST (U/mg protein)

GSH (μg/mg protein)


Control

Group I

1.28 ± 0.35

0.29 ± 0.16

0.09 ± 0.04

2.8 ± 0.7


Terminalia chebula

Group II

2.33 ± 0.24***

0.51 ± 0.22

0.11 ± 0.07

3.35 ± 0.5

Group III

3.14 ± 0.37***

0.74 ± 0.4

0.26 ± 0.05**

3.52 ± 0.5*

Group IV

3.75 ± 0.27***

1.08 ± 0.23*

0.37 ± 0.04***

3.51 ± 0.2


Terminalia belerica

Group V

2.61 ± 0.22***

0.43 ± 0.06

0.15 ± 0.1

3.42 ± 0.3

Group VI

3.62 ± 0.24***

0.65 ± 0.2

0.67 ± 0.15*

4 ± 0.1

Group VII

3.89 ± 0.15***

0.66 ± 0.1**

0.71 ± 0.3

4.04 ± 0.12


Emblica officinalis

Group VIII

2.31 ± 0.18**

0.33 ± 0.2

0.14 ± 0.2

3.04 ± 0.07

Group IX

4.01 ± 0.17***

1.02 ± 0.15**

0.41 ± 0.15*

3.85 ± 0.2

Group X

4.56 ± 0.18***

1.06 ± 0.1**

0.64 ± 0.1**

4.13 ± 0.1


Group I: Control group; Groups II, III and IV represent mice treated orally with the T. chebula extract in the doses of 10, 50 and 100 mg/kg body weight, respectively; Groups V, VI and VII contain mice treated orally with the T. belerica extract in a dose of 10, 50 and 100 mg/kg body weight, respectively; Groups VIII, IX and X represent mice treated orally with the E. officinalis extract in a dose of 10, 50 and 100 mg/kg body weight, respectively. Results are expressed as mean ± SD for six mice in each group.

*p < 0.05, **p < 0.01, ***p < 0.001 compared to control.

Hazra et al. BMC Complementary and Alternative Medicine 2010 10:20   doi:10.1186/1472-6882-10-20

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