Table 2

Number needed to treat for at least 50% pain relief

Improved with

% improved


Number of trials

Drug and dose (mg)

Active

Placebo

Active

Placebo

Relative risk (95% CI)

NNT (95% CI)


Six hour ourcomes

1

Rofecoxib 25

66/115

45/118

57

38

1.5 (1.1 to 2.0)

5.0 (3.7 to 7.8)

3

Rofecoxib 50

140/226

70/225

62

31

2.0 (1.6 to 2.5)

3.2 (2.4 to 4.5)

1

Ibuprofen 400

31/49

10/47

63

21

3.0 (1.7 to 5.4)

2.4 (1.7 to 4.2)

2

Naproxen sodium 550

120/181

60/178

66

34

2.0 (1.6 to 2.5)

3.1 (2.4 to 4.4)

Eight hour ourcomes

1

Rofecoxib 25

70/115

44/118

61

37

1.6 (1.2 to 2.2)

4.2 (2.8 to 9.0)

3

Rofecoxib 50

147/226

73/225

65

32

2.0 (1.6 to 2.5)

3.1 (2.4 to 9.0)

1

Ibuprofen 400

30/47

11/47

61

21

2.6 (1.5 to 4.6)

2.6 (1.8 to 5.1)

2

Naproxen sodium 550

121/181

62/178

68

35

2.0 (1.6 to 2.4)

3.0 (2.3 to 4.3)

Twelve hour ourcomes

1

Rofecoxib 25

64/115

45/118

56

38

1.5 (1.1 to 1.9)

5.7 (3.3 to 20)

3

Rofecoxib 50

135/226

74/225

60

33

1.8 (1.5 to 2.3)

3.7 (2.8 to 5.6)

1

Ibuprofen 400

27/49

12/47

55

26

2.2 (1.3 to 3.7)

3.4 (2.1 to 9.2)

2

Naproxen sodium 550

111/181

62/178

61

35

1.8 (1.4 to 2.2)

3.8 (2.7 to 6.1)


Edwards et al. BMC Women's Health 2004 4:5   doi:10.1186/1472-6874-4-5

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