Table 3

Isoflavone and total phytoestrogen intake and ovarian cancer risk in the NJ Ovarian Cancer Study.

Cases

(n)

Controls

(n)

OR1

95% CI

OR2

95% CI


FROM FOOD

Daidzein (mcg/1000 kcal)

1 (< 20.25)

58

129

1.00

1.00

2 (20.25-144.07)

86

131

1.29

0.81-2.06

1.34

0.83-2.16

3 (≥ 144.08)

61

130

0.80

0.48-1.31

0.88

0.53-1.46

p for trend

0.10

0.21

Genistein (mcg/1000 kcal)

1 (< 40.46)

62

129

1.00

1.00

2 (40.46-247.85)

82

132

1.17

0.74-1.86

1.22

0.76-1.96

3 (≥ 247.86)

61

129

0.75

0.46-1.23

0.83

0.50-1.38

p for trend

0.09

0.21

Formononetin (mcg/1000 kcal)

1 (< 3.90)

78

130

1.00

1.00

2 (3.90-6.80)

75

130

1.01

0.64-1.59

1.02

0.64-1.62

3 (≥ 6.81)

52

130

0.69

0.42-1.14

0.72

0.43-1.22

p for trend

0.11

0.17

Glycitein (mcg/1000 kcal)

1 (< 2.14)

67

130

1.00

1.00

2 (2.14-9.17)

72

131

0.98

0.62-1.57

0.95

0.59-1.53

3 (≥ 9.18)

66

129

0.74

0.46-1.21

0.80

0.48-1.33

p for trend

0.18

0.38

Total Isoflavones (mcg/1000 kcal)

1 (< 70.06)

61

129

1.00

1.00

2 (70.06-404.66)

83

132

1.20

0.76-1.92

1.24

0.77-2.00

3 (≥ 404.67)

61

129

0.78

0.48-1.27

0.86

0.52-1.42

p for trend

0.11

0.24

Matairesinol (mcg/1000 kcal)

1 (< 2.82)

69

129

1.00

1.00

2 (2.82-4.22)

69

131

1.05

0.66-1.67

1.00

0.68-1.78

3 (≥ 4.23)

67

130

1.41

0.88-2.27

1.58

0.97-2.58

p for trend

0.14

0.06

Lariciresinol (mcg/1000 kcal)

1 (< 27.17)

80

130

1.00

1.00

2 (27.17-40.01)

68

131

0.99

0.62-1.57

1.04

0.65-1.66

3 (≥ 40.02)

57

129

0.98

0.60-1.59

1.06

0.64-1.74

p for trend

0.93

0.83

Pinoresinol (mcg/1000 kcal)

1 (< 18.08)

84

129

1.00

1.00

2 (18.08-28.50)

62

132

0.76

0.48-1.20

0.80

0.50-1.29

3 (≥ 28.51)

59

129

0.92

0.58-1.48

0.97

0.59-1.58

p for trend

0.78

0.94

Secoisolariciresinol mcg/1000 kcal)

1 (< 193.64)

63

130

1.00

1.00

2 (193.64-624.92)

84

131

1.27

0.80-2.01

1.33

0.83-2.13

3 (≥ 624.93)

58

129

1.12

0.69-1.80

1.11

0.68-1.81

p for trend

0.81

0.90

Total lignans (mcg/1000 kcal)

1 (< 271.22)

67

129

1.00

1.00

2 (271.22-704.75)

79

131

1.21

0.77-1.91

1.23

0.77-1.97

3 (≥ 704.76)

59

130

1.12

0.70-1.79

1.10

0.68-1.79

p for trend

0.77

0.84

Total phytoestrogens (mcg/1000 kcal)

1 (< 532.28)

80

130

1.00

1.00

2 (532.28-1287.81)

68

131

0.79

0.50-1.25

0.73

0.46-1.16

3 (≥ 1287.82)

57

129

0.68

0.42-1.08

0.73

0.45-1.19

p for trend

0.12

0.29


FROM FOOD and SUPPLEMENTS

Daidzein (mcg/1000 kcal)

1 (< 21.40)

59

130

1.00

1.00

2 (21.40-167.32)

90

131

1.35

0.85-2.15

1.40

0.87-2.26

3 (≥ 167.33)

56

129

0.73

0.44-1.21

0.82

0.49-1.38

p for trend

0.03

0.10

Genistein (mcg/1000 kcal)

1 (< 41.14)

60

130

1.00

1.00

2 (41.14-275.32)

86

131

1.25

0.78-1.99

1.31

0.82-2.11

3 (≥ 275.33)

59

129

0.82

0.50-1.34

0.92

0.55-1.54

p for trend

0.14

0.34

Glycitein (mcg/1000 kcal)

1 (< 2.17)

67

129

1.00

1.00

2 (2.17-11.64)

77

132

1.00

0.63-1.58

0.96

0.60-1.54

3 (≥ 11.65)

61

129

0.70

0.43-1.15

0.76

0.46-1.25

p for trend

0.11

0.24

Total Isoflavones (mcg/1000 kcal)

1 (< 71.80)

60

130

1.00

1.00

2 (71.80-497.97)

86

130

1.29

0.81-2.05

1.35

0.84-2.17

3 (≥ 497.98)

59

130

0.78

0.47-1.28

0.88

0.53-1.46

p for trend

0.08

0.21

Total phytoestrogens (mcg/1000 kcal)

1 (< 534.35)

79

130

1.00

1.00

2 (534.35-1395.56)

74

130

0.88

0.56-1.38

0.82

0.52-1.30

3 (≥ 1395.57)

52

130

0.62

0.38-1.00

0.66

0.41-1.08

p for trend

0.04

0.11


OR1: adjusted for age (continuous), education, race, age at menarche (continuous), menopausal status, parity, OC use, HRT use, BMI (continuous), tubal ligation, and total calories (see methods for more details).

OR2: further adjusted for physical activity (METs for average hours of strenuous or moderate recreational activities per week) and smoking (smoking status and pack-years for current & past smokers). Further adjustment for alcohol intake did not change risk estimates

Bandera et al. BMC Women's Health 2011 11:40   doi:10.1186/1472-6874-11-40

Open Data