Table 3

Efficacy of BKP for malignant spinal fractures: Results of meta-analysis

Variable

Studies providing data

N° patients/levels

Size of effect (95%CI); P-value; I2


Pain: VAS score (0-10)

Basal-postoperative

4 [25,30,33,34]

172 patients

SMD: 3.85 (2.99, 4.71); p < .001; 79%

Baseline-end of follow-up

3 [30,33,34]

109 patients

SMD: 4.27 (2.38, 6.21); p < .001; 93%


Functional capacity:

ODI (0-100)

Baseline-postoperative

4 [25,27,33,34]

173 patients

WMD:-28.78 (-11.5,- 46.0);p = .001; 99%

Baseline-<6 months

2 [25,27]

82 patients

WMD:-16.39 (-14.25,-18.5);p = .001; 0%

Baseline-2 years

2 [33,34]

91 patients

WMD:-41.95 (-39.42, -44.5);p = .001; 0%


Kyphotic deformity (Cobb angle):

Basal-postoperative

3 [26,33,34]

180 levels

SMD:-0.69 (-0.20, -1.16); p = .001; 78%

Baseline-end of follow-up

3 [26,33,34]

155 levels

SMD: -0.39 (0.05, -0.84); p = .08; 74%


Vertebral height:

% of restitution

3 [25,26,30]

342 levels

RR:47% (33%, 61%); 38%

Increase (mm):

2 [33,34]

158 levels

Anterior vertebral body

Basal-postoperative

SMD:0.28 (0.06, 0.51); p = .01; 0%

Baseline-end of follow-up

SMD: 0.15 (-0.16, 0.45); p = .35; 37%

Midline vertebral body

Basal-postoperative

SMD:0.28 (0.003, 0.56); p = .04; 34%

Baseline-end of follow-up

SMD:0.15 (-0.17, 0.46); p = .35; 41%


VAS: Visual Analog Scale. SMD: Standardized mean difference ODI: Oswestry Disability Index. WMD: Weighted mean difference. RR: rate ratio. CI: Confidence Interval. All based on a random effects meta-analysis.

Bouza et al. BMC Palliative Care 2009 8:12   doi:10.1186/1472-684X-8-12

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