|Details of cases recalled by physicians where nebulised frusemide was used|
|Age||Sex||Primary diagnosis||Main problem causing breathlessness||Previous therapies for breathlessness||Impression of clinical efficacy||Comments|
|Case 1||70||Female||NSCL cancer with COPD||Bronchial obstruction||Oxygen, Opioids, Steroids, Benzodiazepines, Bronchodilators, Antibiotics||Possible improvement||No comments provided|
|Case 2||78||Male||Pulmonary oedema||Cardiac failure||Oxygen, Opioids, Benzodiazepines||Unsure of any benefit||No comments provided|
|Case 3||60||Female||CRC, lung metastases, pleural effusion, lymphangitis||Pleural effusion, lymphangitis||Oxygen, Opioids, Steroids, Benzodiazepines, Bronchodilators, Drainage of pleural effusion||Possible improvement||No comments provided|
|Case 4||84||Male||Respiratory failure, History of AF & cardiomyopathy||Pulmonary fibrosis and some mild LVF||Oxygen, Opioids, Nebulised atrovent, Low dose midazolam||Obvious improvement||No comments provided|
|Case 5||70’s||Male||COPD, Lung cancer||COPD, Lung metastases||Oxygen, Opioids, Steroids, Benzodiazepines, Bronchodilators, Antibiotics||Possible improvement||No comments provided|
|Case 6||65||Male||Not reported||Not reported||Oxygen, Opioids, Steroids, Benzodiazepines||Possible improvement frusemide||No comments provided|
|Case 7||60’s||Female||Stage IV NSCLC||Cardiac failure||Oxygen, Opioids, Steroids, Benzodiazepines, Bronchodilators, Antibiotics||Possible improvement||No comments provided|
|Case 8||37||Female||Lung cancer||Local disease, airway compromise, effusion||Oxygen, Opioids, Steroids, Bronchodilators||Obvious improvement||She was quite anxious and benzo’s used helped significantly but further improvement seen after adding lasix as well|
|Case 9||72||Female||Metastatic vulval cancer||Pleural effusion||Oxygen, Opioids, Steroids, Glycopyrolate||Obvious improvement||Within 20 minutes, patient came out of unconsciousness. I am considering using now as first line with atrovent when acute episode occurs after chronic control.|
|Case 10||70’s||Male||Respiratory failure||End stage COPD||Oxygen, Opioids, Steroids, Benzodiazepines, Bronchodilators, Antibiotics||Obvious improvement||Addition of nebulised frusemide improved difficult dyspnea, where all other modalities had been tried;|
NSCL Non-small cell carcinoma of the lung; COPD Chronic obstructive pulmonary disease; CRC colorectal cancer; AF atrial fibrillation; IHD: Ischemic heart disease.
Newton et al.
Newton et al. BMC Palliative Care 2012 11:6 doi:10.1186/1472-684X-11-6