Table 2

Silver dose and serum silver pharmacokinetics after application of diammine silver fluoride topically
Subject Silver applied (mg)a Silver - RfDbNOAELcfor subject (mg)d Time to maximum serum concentration (h) Maximum serum silver (nmol/L)
1 0.75 0.24 2.0 28
2 1.63 0.27 2.1 269
3 1.15 0.42 4.0 250
4 1.51 0.41 3.0 213
5 2.37 0.27 1.0 269
6 1.61 0.28 3.0 204

aCalculated based on volume of DSF solution applied times 0.249 mg/μL.

bRfD = U.S. Environmental Protection Agency oral reference dose.

c NOAEL = no observable adverse effect level.

dCalculated based on subject weight (kg) times NOAEL RfD of 0.005 mg/(kg d).

Vasquez et al.

Vasquez et al. BMC Oral Health 2012 12:60   doi:10.1186/1472-6831-12-60

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