Table 3

Details of identified research gaps in clinical topics related to trial precision
Research gap Details
Imprecision of results [A]
    Too few clinical trials
Caries on restoration margins on permanent teeth: C-GIC tooth restorations vs. Amalgam tooth restorations [4]
Caries on restoration margins on primary teeth: C-GIC tooth restorations vs. Amalgam tooth restorations [4]
Success of restorations in permanent teeth: ART vs. Amalgam tooth restorations (Class II), (Class V) [5]
Success of Class II restorations in primary teeth: ART vs. Amalgam tooth restorations [5]
Caries lesions on adjacent permanent teeth: RM-GIC vs. Composite restorations (F), (NF) [6]
Carious lesions around orthodontic brackets: RM-GIC vs. Composite bonding (NF) [7]
Caries on restoration margins on primary teeth: RM-GIC vs. Composite restorations (F), (NF) [7]
Caries on restoration margins on permanent teeth: RM-GIC vs. Composite restorations (F), (NF) [7]
Caries-free restoration margins on permanent teeth: C-GIC vs. RM-GIC restorations [9]
Pulp response on teeth with deep caries: RM-GIC vs. CaOH cement [10]
    Sample size too small
Caries on restoration margins on primary teeth: C-GIC tooth restorations vs. Amalgam tooth restorations [4]
Success of restorations in permanent teeth: ART vs. Amalgam tooth restorations (Class II), (Class V) [5]
Carious lesions around orthodontic brackets: RM-GIC vs. Composite bonding (NF) [7]
Caries on restoration margins on permanent teeth: RM-GIC vs. Composite restorations (NF) [7]
Pulp response on teeth with deep caries: RM-GIC vs. CaOH cement [10]
    Confidence intervals (95% CI) wide enough to include superiority and inferiority
Caries-free restoration margins on permanent teeth: C-GIC vs. RM-GIC restorations [9]
Inconsistency of results [B]
    Contradicting directions of effect sizes/Large differences between effect sizes
Caries on pits and fissures of sealed permanent teeth: C-GIC vs. resin-based sealants [3]
Carious lesions around orthodontic brackets: RM-GIC vs. Composite bonding (NF) [7]
Caries on restoration margins on permanent teeth: RM-GIC vs. Composite restorations (NF) [7]
    Unexplained heterogeneity
Caries on pits and fissures of sealed permanent teeth: C-GIC vs. resin-based sealants [3]
    Only 1 trial found – no assessment of consistency possible
Success of restorations in permanent teeth: ART vs. Amalgam tooth restorations (Class II) [5]
Caries lesions on adjacent permanent teeth: RM-GIC vs. Composite restorations (F), (NF) [6]
Caries on restoration margins on primary teeth: RM-GIC vs. Composite restorations (F), (NF) [7]
Caries on restoration margins on permanent teeth: RM-GIC vs. Composite restorations (F) [7]
Lack of right information [C]
    Only/mostly surrogate outcomes accessed
Caries lesions on adjacent permanent teeth: RM-GIC vs. Composite restorations (F), (NF) [7]
Pulp response on teeth with deep caries: RM-GIC vs. CaOH cement [10]

GIC = Glass-ionomer cement; RM-GIC = Resin-modified GIC; C-GIC = Conventional GIC; ART = Atraumatic restorative treatment (C-GIC based); (F) = Containing fluoride; (NF) = Not containing fluoride; T = Topic; CaOH = Calcium hydroxide cement.

Mickenautsch

Mickenautsch BMC Oral Health 2012 12:18   doi:10.1186/1472-6831-12-18

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