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Decision criteria |
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| Criterion |
Definition |
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| Thyrotropic insufficiency |
a) Reduced levels of both TSH and free T4. b) Thyrotroph T4 Sensitivity Index (TTSI) reduced below its reference interval. |
| Reduced plasma protein binding |
a) Reduced relative ratios of bound and free hormone levels b) Reduced apparent dissociation constant of T3 at thyroxin binding globulin (K30) |
| Reduced deiodation |
a) Reduced level for free T3 b) diminished T3/T4-ratio c) reduced sum activity of peripheral 5'-Dejodinase (GD^) |
Dietrich et al. BMC Endocrine Disorders 2008 8:13 doi:10.1186/1472-6823-8-13 |
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