Figure 3.

Diurnal rhythm of serum estradiol during pubertal development in healthy boys. For each study subject, the percentage difference from the mean value/24 h was calculated every four hours before dividing into pubertal groups. Data are shown as the mean value ± standard error of the mean for each pubertal group and clock time. Data is based on 17 boys in early puberty with testicular volume 3–6 mL, 10 boys in mid-puberty with testicular volume 8–12 mL, 10 boys in late puberty, with testicular volume 15–25 mL who have not reached final height and 9 boys in late puberty, with testicular volume 15–25 mL who have reached final height.