Table 3

Eight-hour studies with glucagon-like peptide 1. Effects of vehicle or 0.63 μg/kg subcutaneous GLP-1 and usual insulin at breakfast and lunch in paired studies in 9 volunteers with type 1 diabetes with no endogenous insulin secretion. Time-averaged incremental values (area under the curve divided by time) for plasma glucose through eight hours and for plasma pancreatic polypeptide from 0 to 30 min for both meals (HPP), and mean values for incremental plasma glucagon through 60 min for both meals, mean ± SE.

Glucose mmol/l

HPP pmol/l

Glucagon ng/l


Vehicle

5.4 ± 0.8

37 ± 9.6

3.1 ± 1.7

GLP1

3.2 ± 0.9*

4.0± 3.1*

-3.7 ± 2.5*


*P < .05, paired t-tests for GLP-1 compared to vehicle

Behme et al. BMC Endocrine Disorders 2003 3:3   doi:10.1186/1472-6823-3-3

Open Data