|
Dose effect of glucagon-like peptide 1. Effects of graded doses of GLP-1 and usual insulin before breakfast in volunteers with type 1 diabetes with no endogenous insulin secretion, with number of subjects studied at each dose. Time-averaged incremental (delta) responses (area under the curve divided by total time) of plasma glucose through 3 hours, pancreatic polypeptide(HPP), 0 to 30 min, and glucagon, 0 to 60 min, mean ± se. Polynomial regression analysis (R2) for dose vs incremental responses. |
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| Dose μg/kg |
n |
Glucose mmol/l |
HPP pmol/l |
Glucagon ng/l |
|
|
||||
| 0 |
15 |
6.5 ± 0.8 |
27.4 ± 4.6 |
11.9 ± 3.7 |
| 0.32 |
9 |
5.8 ± 1.7 |
14.1 ± 6.4 |
8.5 ± 4.5 |
| 0.63 |
12 |
5.2 ± 0.8 |
3.1 ± 2.2 |
6.6 ± 2.5 |
| 1.25 |
11 |
4.7 ± 0.8 |
1.7 ± 0.89 |
5.1 ± 6.7 |
|
|
||||
| R2 |
0.99 |
0.99 |
||
Behme et al. BMC Endocrine Disorders 2003 3:3 doi:10.1186/1472-6823-3-3 |
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