Table 2

Dose effect of glucagon-like peptide 1. Effects of graded doses of GLP-1 and usual insulin before breakfast in volunteers with type 1 diabetes with no endogenous insulin secretion, with number of subjects studied at each dose. Time-averaged incremental (delta) responses (area under the curve divided by total time) of plasma glucose through 3 hours, pancreatic polypeptide(HPP), 0 to 30 min, and glucagon, 0 to 60 min, mean ± se. Polynomial regression analysis (R2) for dose vs incremental responses.

Dose μg/kg

n

Glucose mmol/l

HPP pmol/l

Glucagon ng/l


0

15

6.5 ± 0.8

27.4 ± 4.6

11.9 ± 3.7

0.32

9

5.8 ± 1.7

14.1 ± 6.4

8.5 ± 4.5

0.63

12

5.2 ± 0.8

3.1 ± 2.2

6.6 ± 2.5

1.25

11

4.7 ± 0.8

1.7 ± 0.89

5.1 ± 6.7


R2

0.99

0.99


Behme et al. BMC Endocrine Disorders 2003 3:3   doi:10.1186/1472-6823-3-3

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