Polymorphisms in GC and NADSYN1 Genes are associated with vitamin D status and metabolic profile in Non-diabetic adults
1 Research group Clinical Epidemiology and MedicineResearch group, University of Antilles and Guyane, Guyane, France
2 Department of Public Health and Medical Information, University Hospital of Pointe-à-Pitre, Guadeloupe, France
3 Diabetology Unit, University Hospital of Pointe-à-Pitre, Guadeloupe, France
4 Health Centre, AGREXAM, Les Abymes, Guadeloupe, France
5 Clinical Genetic Unit, University Hospital of Pointe-à-Pitre, Guadeloupe, France
6 Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, PA, USA
7 Endocrinology-Diabetology and nutrition Unit, University Hospital South of Rennes, Rennes, France
8 Nephrology Unit, University Hospital of Pointe-à-Pitre, Guadeloupe, France
9 Département de Santé Publique, CHU de Pointe-à-Pitre, 97159 Pointe-à-Pitre, Guadeloupe, France
BMC Endocrine Disorders 2013, 13:36 doi:10.1186/1472-6823-13-36Published: 29 September 2013
Our aim was to assess the associations between vitamin D (vitD) status, metabolic profile and polymorphisms in genes involved in the transport (Group-Component: GC) and the hydroxylation (NAD synthetase 1: NADSYN1) of 25 hydroxyvitamin D (25(OH)D) in non-diabetic individuals.
We conducted a cross-sectional study with 323 individuals recruited from the Health Center of Guadeloupe, France. The rs2282679 T > G and rs2298849 T > C in GC and rs12785878 G > T in NADSYN1 were genotyped.
Mean age was 46(range 18–86) years. 57% of participants had vitD insufficiency, 8% had vitD deficiency, 61% were overweight and 58% had dyslipidemia. A higher frequency of overweight was noted in women carrying rs2298849T allele v CC carriers (71% v 50%; P = 0.035). The rs2282679G allele was associated with increased risks of vitD deficiency and vitD insufficiency (OR =3.53, P = 0.008, OR = 2.34, P = 0.02 respectively). The rs2298849 TT genotype was associated with vitD deficiency and overweight (OR =3.4, P = 0.004 and OR = 1.76, P = 0.04 respectively) and the rs12785878 GG genotype with vitD insufficiency and dyslipidemia (OR = 1.80, P = 0.01 and OR = 1.72, P = 0.03 respectively). Based on the number of risk alleles for rs2282679 and rs12785878 combined, a genotype score of 3 (vs. 0–1) was associated with a 5.5 ng/mL average reduction in serum 25(OH)D levels (P = 0.001).
The GC and NADSYN1 genes are associated with the vitamin D status and might contribute to dyslipidemia and overweight independently of 25(OH)D levels.