Open Access Highly Accessed Research article

The association of hypertriglyceridemia with cardiovascular events and pancreatitis: a systematic review and meta-analysis

M Hassan Murad12*, Ahmad Hazem123, Fernando Coto-Yglesias1, Svitlana Dzyubak1, Shabnum Gupta1, Irina Bancos15, Melanie A Lane1, Patricia J Erwin1, Lars Berglund4, Tarig Elraiyah1 and Victor M Montori15

Author Affiliations

1 Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN, USA

2 Division of Preventive Medicine, Mayo Clinic, Rochester, MN, USA

3 Department of Internal Medicine, University of North Dakota, Fargo, ND, USA

4 Davis and the VA Northern California Health Care System, University of California, Sacramento, USA

5 Division of Endocrinology, Diabetes, Metabolism, Nutrition, Mayo Clinic, Rochester, MN, USA

For all author emails, please log on.

BMC Endocrine Disorders 2012, 12:2  doi:10.1186/1472-6823-12-2

Published: 31 March 2012

Abstract

Background

Hypertriglyceridemia may be associated with important complications. The aim of this study is to estimate the magnitude of association and quality of supporting evidence linking hypertriglyceridemia to cardiovascular events and pancreatitis.

Methods

We conducted a systematic review of multiple electronic bibliographic databases and subsequent meta-analysis using a random effects model. Studies eligible for this review followed patients longitudinally and evaluated quantitatively the association of fasting hypertriglyceridemia with the outcomes of interest. Reviewers working independently and in duplicate reviewed studies and extracted data.

Results

35 studies provided data sufficient for meta-analysis. The quality of these observational studies was moderate to low with fair level of multivariable adjustments and adequate exposure and outcome ascertainment. Fasting hypertriglyceridemia was significantly associated with cardiovascular death (odds ratios (OR) 1.80; 95% confidence interval (CI) 1.31-2.49), cardiovascular events (OR, 1.37; 95% CI, 1.23-1.53), myocardial infarction (OR, 1.31; 95% CI, 1.15-1.49), and pancreatitis (OR, 3.96; 95% CI, 1.27-12.34, in one study only). The association with all-cause mortality was not statistically significant.

Conclusions

The current evidence suggests that fasting hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.

Précis: hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis

Keywords:
Hypertriglyceridemia; Cardiovascular disease; Pancreatitis; Systematic reviews and meta-analysis