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Open Access Highly Accessed Case report

Pleomorphic adenoma of minor salivary gland with therapeutic misadventure: a rare case report

Jagdeep S Thakur1*, Narinder K Mohindroo1, Shobha Mohindroo2, Dev R Sharma1 and Anamika Thakur3

Author Affiliations

1 Department of Otolaryngology - Head & Neck Surgery, I. G. Medical College, Shimla, HP, 171001, India

2 Department of Pathology, I. G. Medical College, Shimla, HP, 171001, India

3 Department of Pharmacology, I. G. Medical College, Shimla, HP, 171001, India

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BMC Ear, Nose and Throat Disorders 2010, 10:2  doi:10.1186/1472-6815-10-2

Published: 8 January 2010

Abstract

Background

The benign tumors of nasopharynx are least encountered tumors in otolaryngology, as nasopharynx is considered one of notorious anatomical site for the malignant tumors. Pleomorphic adenoma of the minor salivary gland of nasopharynx and parapharyngeal space is rare. We present a pleomorphic adenoma of minor salivary gland which was mismanaged.

Case presentation

An adult male presented with left nostril obstruction for five months. The examination found big mass extending from nasopharynx to oropharynx. On CT scan, this tumor was quite big and extending to the parapharyngeal space. The FNAB found it a carcinoma but it did not respond to radiotherapy. The excision biopsy of tumor revealed it as pleomorphic adenoma. We found only five published reports on this tumor arising from nasopharynx.

Discussion and conclusion

Although, in this case report exact origin of the tumor could not be ascertained as it also appeared to be a parapharyngeal tumor but we kept the possibility of a nasopharyngeal tumor on the basis of clinical features. The pleomorphic adenoma of nasopharynx is rare. It can be misdiagnosed as malignant epithelial tumor on histopathology. The differentiation from its malignant variant is also difficult. A possibility of benign tumor should always be kept in nasopharyngeal growth with no evidence of metastasis, and histopathological diagnosis of growth should be available before any definitive treatment.