Figure 4.

Electrostatic energy interactions in B-RAF^WT, B-RAF^D594V and B-RAF^K601E. A) The total electrostatic interaction energies between the A-loop and the P-loop in B-RAF^WT, B-RAF^D594V and B-RAF^K601E. B) The electrostatic interaction energy between the A-loop and the αC-helix, and the A-loop-1 (residues 593–602, the A-loop portion solved in the crystal structures) and the αC-helix in B-RAF^K601E. C) The electrostatic interaction energy between the A-loop and the αC-helix, and the A-loop-1 and the αC-helix in B-RAF^D594V.