Research article
Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study
1 Department of Biochemistry, Abbott Laboratories, Worcester, MA USA
2 Department of Molecular Pharmacology, Abbott Laboratories, Worcester, MA USA
3 Department of Molecular Cell Biology, Abbott Laboratories, Worcester, MA USA
4 Present address : Department of Physical Biochemistry, Biogen Idec, Cambridge, MA USA
5 Present address : Department of Process Sciences, Abbott Laboratories, Worcester, MA USA
6 Present address : 119 North Swain Street, Raleigh, NC 27601, USA
7 Present address : Protein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, CA USA
8 Present address : Department of Biologics, Abbott Laboratories, Worcester, MA USA
9 Present address : D. E. Shaw Research, New York, NY USA
BMC Structural Biology 2009, 9:16 doi:10.1186/1472-6807-9-16
Published: 18 March 2009Additional files
Additional file 1:
Complete list of MK2 expression constructs and MK2 robotic crystallization screen used for identification of crystallization hits. Table S7 is a complete listing of MK2 expression constructs with crystal forms identified. Table S8 is a complete matrix listing of the crystallization screen used in the identification of crystallization hits.
Format: DOC Size: 163KB Download file
This file can be viewed with: Microsoft Word Viewer
