Representations of channel surfaces. Comparison of (A) MOLE tunnel, (B) selected molecular surface, (C) and HOLLOW surface. The periplasmic opening (black box) and the cytoplasmic opening (grey box) regions show a clear loss of detail in the MOLE tunnel and superfluous detail in the selected molecular surface. The "gating" region of the periplasmic vestibule (dashed box) and the cytoplasmic vestibule (dotted box) exhibit comparable detail in the selected surface and HOLLOW surface, while the MOLE tunnel lacks the details necessary for the representation of the channel lumen.
Ho and Gruswitz BMC Structural Biology 2008 8:49 doi:10.1186/1472-6807-8-49