Energy landscape. Due to energy barriers, some models need to be nudged in order to fall into their optimal energy basins. A relatively small change in structural conformation can have a marked effect on a model's energy; SC scores are given along the energy landscape (top and bottom). A curved representation is chosen to highlight the three-dimensional nature of energy landscapes. Dark circles are conformations that are scored; light grey circles are non-scored, intermediate, conformations. In case (a) one non-scored intermediate conformation is needed to climb a small energy barrier. A more difficult case is shown in (b), where a maximum of two consecutive intermediate conformations are required, before energy evaluation. Case (c) shows a scenario where no intermediate conformation is required.
Offman et al. BMC Structural Biology 2008 8:34 doi:10.1186/1472-6807-8-34