Open Access Research article

CUSP: an algorithm to distinguish structurally conserved and unconserved regions in protein domain alignments and its application in the study of large length variations

Sankaran Sandhya1, Barah Pankaj12, Madabosse Kande Govind1, Bernard Offmann3, Narayanaswamy Srinivasan4 and Ramanathan Sowdhamini1*

Author Affiliations

1 National Centre for Biological Sciences (TIFR), UAS-GKVK Campus, Bellary Road, Bangalore 560 065, India

2 Mathematical modeling and Computational Biology group, Centre for Cellular and Molecular Biology, Hyderabad, India

3 Laboratoire de Biochimie et Génétique Moléculaire, Université de La Réunion, La Réunion, France

4 Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India

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BMC Structural Biology 2008, 8:28  doi:10.1186/1472-6807-8-28

Published: 31 May 2008

Additional files

Additional file 1:

CUSP: an algorithm to distinguish structurally conserved and unconserved protein domain alignments and its application in the study of large length variations. The data provided represent the various analysis carried out to determine and describe the length variation in the dataset (Section I: S1–S5) and also contains an example of the functional implications of indels in Cytochrome C domain superfamily (Section II). Additional figures and tables that support the data in the main text are also included.

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