Exploring allosteric coupling in the α-subunit of Heterotrimeric G proteins using evolutionary and ensemble-based approaches

Kemal Sayar¹^,2 , Özlem Uğur¹ , Tong Liu³ , Vincent J Hilser³ and Ongun Onaran¹^,2

¹Ankara University Faculty of Medicine, Department of Pharmacology and Clinical Pharmacology, Sıhhiye 06100, Ankara, Turkey

²Ankara University Faculty of Medicine, and Molecular Biology and Technology Research and Development Unit, Sıhhiye 06100, Ankara, Turkey

³Department of Biochemistry and Molecular Biology, and Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, 77555-1068 USA

author email corresponding author email

BMC Structural Biology 2008, 8:23doi:10.1186/1472-6807-8-23


Published:	2 May 2008

Additional files

Additional file 1:

supporting information. A simulation test for the comparison of the measure of statistical coupling in MSA that was used in the present study with the one that has been originally suggested by Lockless and Ranganathan (ref 23) is provided as supporting information.

Format: PDF Size: 135KB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional file 2:

Statistical coupling matrix. Entire statistical coupling matrix for the G protein family is given as supporting data (as an MSExcel file) for further analysis.

Format: XLS Size: 2.2MB Download file

This file can be viewed with: Microsoft Excel Viewer