Figure 4.

Charge stabilisation of phosphorylated sites in biological units. (a) Phosphorylated and background sites in the dataset culled at 25% sequence identity. (b) Phosphorylation site stabilisation at a protein-protein interface. An extended segment of phosphorylated serotonin N-acetyltransferase (AANAT) (mainchain, cyan and TPO 31, pink) binds to 14-3-3 (orange mainchain), with surrounding residues colour-coded by type (blue basic, red acidic, yellow polar uncharged, grey non-polar).