Figure 1.

Side view of the LOX-1 CTLD structure. The α-helices are shown as red spiral ribbons while β-strands are shown as green arrows. The wire regions indicate the random-coil structure and the turns. The side chains of cysteines involved in disulfide bridges and the mutated tryptophan are evidenced by the yellow and blue ball-and-stick representation, respectively. A cyan molecular surface has been superimposed to show the large central cavity and the small cavity below the tryptophans. This picture was produced by using the programs Molscript [36] and Pymol [37].