Table 10

Spectrum of mutations in β-strands in amino acid groupsa

Amino acid group

Original residues

Expected residues

χ2

P value

Mutant residues

Expected residues

χ2

P value


Hydrophobic

241

285

6.72**

9.54E-03

170

191

2.27

1.32E-01

Positively charged

38

40

0.12

7.31E-01

46

42

0.36

5.47E-01

Negatively charged

113

65

35.48***

2.58E-09

115

90

7.07**

7.82E-03

Conformational

59

39

10.86***

9.81E-04

74

66

0.98

3.21E-01

Polar

44

53

1.62

2.03E-01

95

94

0.01

9.18E-01

A+T

55

68

2.58

1.08E-01

50

67

4.47*

3.45E-02


Sum

550

550

550

550


aχ2-numbers in italics indicate underrepresentation and numbers in bold overrepresentation compared to random distribution based on amino acid frequencies. The results of the χ2 are shown with significance level: * P < 0.05; ** P < 0.01; *** P < 0.001.

Khan and Vihinen BMC Structural Biology 2007 7:56   doi:10.1186/1472-6807-7-56

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