Table 5 |
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|
Structure-based calculation of the thermodynamic parameters of binding between p41 and R21A Spc-SH3 and Abl-SH3 domain. |
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|
Protein |
Buried water molecules1 |
ΔHb (kJ mol-1) |
T ΔSb (kJ mol-1) |
ΔGb (kJ mol-1) |
ΔCp,b (kJ K-1mol-1) |
|
|
|||||
|
R21A Spc-SH3 |
No water |
28.5 |
46.5 |
-18.0 |
-1.0 |
|
2 bound water molecules |
-1.0 |
27.4 |
-28.4 |
-0.84 |
|
|
|
|||||
|
Abl-SH3 |
No water |
21.6 |
41.4 |
-19.8 |
-0.98 |
|
5 bound water molecules |
-58.5 |
-9.6 |
-49.1 |
-0.47 |
|
|
|
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|
1Water molecules present in the bound state and not present in the unbound state were considered to contribute to the solvent accessible surface area of the unbound state as a fully exposed molecule. |
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|
Casares et al. BMC Structural Biology 2007 7:22 doi:10.1186/1472-6807-7-22 |
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