Table 1

Gibbs free energies and specific volumes^a
Domain	Transition	K₀	ΔG₀[kJ mol^-1]	ΔV₀[ml mol^-1]	ΔV₀[nm³]

huPrP(23–230)
amino acid 23–120	N₁▶ N₂	0.292	3.0 ± 1.1	-63 ± 11	-0.10 ± 0.02
	N ▶ I	n. d.	n. d.	n. d.	n. d.
amino acid 121–230	N₁▶ N₂	0.300	2.9 ± 1.3	-79 ± 15	-0.13 ± 0.02
	N ▶ I	n. d.	n. d.	n. d.	n. d.

huPrP(121–230)
amino acid 121–230	N₁▶ N₂	0.292	3.0 ± 1.4	-86 ± 17	-0.14 ± 0.03
	N ▶ I₁	0.012	10.8 ± 1.9	-66 ± 26	-0.11 ± 0.04
	N ▶ I₂	0.0005	18.6 ± 2.9	-125 ± 32	-0.21 ± 0.05

^aData were measured at 293 K and represent the average of the residues in the corresponding domains. K₀and ΔG₀are the values calculated for 293 K and 0.1 MPa.
Kachel et al. BMC Structural Biology 2006 6:16 doi:10.1186/1472-6807-6-16