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Open Access Highly Accessed Commentary

Reliable structural interpretation of small-angle scattering data from bio-molecules in solution - the importance of quality control and a standard reporting framework

David A Jacques, Jules Mitchell Guss and Jill Trewhella*

Author Affiliations

School of Molecular Bioscience Building, University of Sydney, G08 Butlin Avenue, Sydney, NSW, 2006, Australia

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BMC Structural Biology 2012, 12:9  doi:10.1186/1472-6807-12-9

Published: 17 May 2012

Abstract

Small-angle scattering is becoming an increasingly popular tool for the study of bio-molecular structures in solution. The large number of publications with 3D-structural models generated from small-angle solution scattering data has led to a growing consensus for the need to establish a standard reporting framework for their publication. The International Union of Crystallography recently established a set of guidelines for the necessary information required for the publication of such structural models. Here we describe the rationale for these guidelines and the importance of standardising the way in which small-angle scattering data from bio-molecules and associated structural interpretations are reported.

Keywords:
Small-angle scattering; Protein structure; Reporting framework; Standards; Quality control