Table 3

Crystallographic statistics for Tyk2/Compound 1 and Tyk2/Compound 2 complexes
Structure Tyk2/ Compound 1 Tyk2/ Compound 2
PDB entry 4E20 4E1Z
Data Collection
Resolution (Å) 50.0–2.60 20.0–2.50
(Highest shell, Å) 2.64–2.60 2.54–2.50
Space Group P3121 P3121
Unit Cell Lengths (a, b, c; Å) 67.3, 67.3, 154.9 68.0, 68.0, 153.0
Unique reflections 13,121 14,608
Mosaicity (°) 0.247 0.642
Overall Statistics (Highest Shell)
Rsym (%) 0.085 (0.511) 0.055 (0.480)
I/σI 8.9 (2.5) 9.2 (2.3)
Data completeness (%) 99.9 (100) 98.3 (97.4)
Mean multiplicity 6.9 (5.1) 6.8 (4.7)
Refinement
Reflections used in refinement 13,072 13,973
Rcryst (%) 19.9 19.8
Rfree (%) 23.2 24.3
R.m.s. deviations, bond lengths (Å), bond angles (°) 0.010, 1.15 0.010, 1.20
Ramachadran plot
Most favored (%) 96.4 96.1
Allowed (%) 2.2 3.2
Disallowed (%) 1.5 0.7

Argiriadi et al.

Argiriadi et al. BMC Structural Biology 2012 12:22   doi:10.1186/1472-6807-12-22

Open Data