Difference in frequency of each amino acid type on the inner cavity surface between psychrophilic and the mesophilic paired proteins. Psychrophilic enzymes have a larger number of acidic side chains on the inner surface of a cavity (p < 0.01). Mesophilic enzymes have a larger number of hydrophobic residues (p < 0.01).
Paredes et al. BMC Structural Biology 2011 11:42 doi:10.1186/1472-6807-11-42