|
Activity effects on hemodynamics of PAR2 -/- and PAR2 +/+ mice. |
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| Time Period |
Variable |
PAR2 +/+ |
PAR2 -/- |
Ratio PAR2 -/- to PAR2 +/+ |
|
|
|
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| 12 h dark |
% time active |
52 ± 1 |
49 ± 2 |
0.96 |
|
| Act intensity |
1.15 ± 0.01 |
1.17 ± 0.02 |
1.02 |
||
| SAP inactive (mmHg) |
125 ± 1 |
* |
128 ± 1 |
1.02 |
|
| SAP active (mmHg) |
137 ± 1 |
*** |
142 ± 1 |
1.04 |
|
| DAP inactive (mmHg) |
95 ± 1 |
96 ± 1 |
1.01 |
||
| DAP active (mmHg) |
106 ± 1 |
109 ± 1 |
1.03 |
||
| PP inactive (mmHg) |
29 ± 1 |
* |
33 ± 1 |
1.14 |
|
| PP active (mmHg) |
31 ± 1 |
* |
34 ± 1 |
1.10 |
|
| HR inactive (beats min-1) |
572 ± 6 |
581 ± 5 |
1.02 |
||
| HR active (beats min-1) |
640 ± 6 |
** |
663 ± 6 |
1.04 |
|
|
|
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| 12 h light |
% time active |
28 ± 1 |
26 ± 1 |
0.93 |
|
| Act intensity |
1.01 ± 0.02 |
0.98 ± 0.02 |
0.97 |
||
| SAP inactive (mmHg) |
112 ± 1 |
* |
117 ± 1 |
1.04 |
|
| SAP active (mmHg) |
131 ± 1 |
** |
136 ± 1 |
1.04 |
|
| DAP inactive (mmHg) |
84 ± 1 |
85 ± 1 |
1.01 |
||
| DAP active (mmHg) |
100 ± 1 |
102 ± 1 |
1.02 |
||
| PP inactive (mmHg) |
28 ± 1 |
* |
32 ± 1 |
1.14 |
|
| PP active (mmHg) |
31 ± 1 |
* |
34 ± 1 |
1.10 |
|
| HR inactive (beats min-1) |
543 ± 4 |
544 ± 6 |
1.00 |
||
| HR active (beats min-1) |
628 ± 4 |
634 ± 5 |
1.01 |
||
|
Telemetry data from 12 hour light and 12 hour dark periods were obtained from 33 PAR2 +/+ and 21 PAR2 -/- mice. Hemodynamic data were matched to locomotor activity status. Values are mean ± standard error of means. P values determined by multiple comparisons testing between strains during light and dark periods using 2 way ANOVA and Bonferroni post-hoc. *, P < 0.05; **, P < 0.01; ***, P < 0.001. | |||||
McGuire et al. BMC Physiology 2008 8:20 doi:10.1186/1472-6793-8-20 |
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